In the present study, the compressive strength and water absorption of the concrete with different amounts of CuO nanopowders have been investigated. CuO nanopowders as 1 up to 4 wt% were added to the concrete binder as a partial replacement of the cement and various the properties of the specimens were measured. The results indicate that CuO nanopowders decrease the workability of the fresh concrete while improving the consistency of the mixture. They are able to improve the compressive strength of concrete and reduce water absorption of the concrete which could lead to improved durability of concrete. SEM investigation of concrete microstructure also confirmed improved and denser microstructure of nanopowder-containing mixture compared to plain mixture at the age of 28 days. CuO nanopowders as a partial replacement of cement could accelerate C–S–H gel formation at the early ages of hydration and thereby more strength development and less water absorption.

The main aim of the paper is analysis of the region, innovation and knowledge in\nstrategy of the European Union economic growth and social security. To the\nparticular goals of the research belong the presentation the innovation system and\nknowledge in the creation of enterpreneurship, theoretical concept of innovation\nsystem and innovation process at the level of the region, knowledge-based\neconomy, constructed advantage, Triple Helix model constructed advantage,\nEurope 2020 strategy, Innovation Union and Horizon 2020 as the financial\ninstrument implementing the Innovation Union. The important results of the\nresearch is the conclusion that in the innovation process very important are the\nconnection between science (universities), market (industry) and government.\nThere is positive dependence between innovation activity and effectiveness of the\ninnovation process. The more interaction and cooperation it can observe on the\nregional level than on the state. The new programme of the scientific and\ninnovation research Europe 2020 and Innovation Union are very important factors\nin strategy of the European Union economic growth and social security.

Colorectal cancer is one of the most commonly diagnosed cancers and is a leading cause for cancer related death worldwide. PTEN gene also plays a very distinct role in the early stages of embryonic development such as cell migration, proliferation and migration which is a tumor suppressor gene that is mutated and/or deleted in many types of tumor. Nevertheless, little is known of the function of PTEN in colorectal carcinoma during cell proliferation and migration. To examined the expression of PTEN in human colorectal cancer cell lines HCT-8. We found that PTEN expression decreased in well differentiated cells comparing to poorly differentiated cells. To further investigate the functions of PTEN in colorectal cancer cells, we established stably transfected HCT-8 cell lines expressing siRNA targeting the PTEN gene. Cell proliferation and cell migration of the siPTEN cells were characterized by the CCK-8 assay and the transwell assay, respectively. Our results showed that constitutive knocking down of the PTEN gene in siPTEN cells significantly promoted cell proliferation and migration. These results suggest that PTEN may play important roles in colorectal cancer cell proliferation and migration.

E-learning is becoming a learning approach within greater academic settings because of the quick development associated with Web systems. E-learning may be the utilization of information and communication technology (ICT) to improve and help teaching and learning. This particular research looks at the use of e-learning to describe popularity from the e-learning technology inside the educational environments. In so doing, a questionnaire came back from 213 had been 177. 19% from the participants had been female college students whilst 81% had been male. A simple linear regression analysis had been carried out to accept or reject the null hypotheses mentioned. The findings indicated that E-learning would enhance students’ educational overall academic achievement. Suggestions had been that instruction and information periods upon e-learning have to be concentrated mainly on how the e-learning technologies might help enhance the effectiveness and usefulness associated with students’ learning procedure.

The in-vitro urease inhibitory activity of fixed oil and various organic fractions of Caralluma Tuberculata followed by GC-MS analysis of fixed oils are described in this research article. The fixed oils caused marked attenuation of jeck bean urease with half-maximal inhibitory concentration (IC50) of 2.97 mg mL-1. The similar inhibitory urease profile was observed for chloroform and ethyl acetate fractions with IC50 values of 3.36 and 4.90 mg mL-1 respectively. GC-MS analysis led to the identification of 21 different constituents of fixed oils by their m/z ratio and retention time in comparison with standard. The major constituents were linoleic acid, methyl ester (19.65%) followed by palmitic acid, methyl ester (13.75%) and oleic acid, methyl ester (9.36%). In conclusion, fixed oils and organic fractions of C. Tuberculata exhibited marked urease inhibition and thus provided scientific background for the uses of the plant as antiulcer.

Introduction\n Residential and agricultural pesticide use is widespread in the world . Their extensive and indiscriminative use , in addition with their ability to interact with biological systems other than their primary targets constitute a health hazards to both humans and animals. The toxic effects of pesticides include alterations in metabolism , there is a lack of knowledge that organophosphates can cause pancreatic toxicity.\nAim of the Work\nThe primary goal of this work is to study the effects of chronic exposure to diazinon an organophosphate used in agriculture on pancreatic tissues and evaluate the ameliorating effect of mesna as antioxidant on the toxicity of diazinon on pancreatic tissues.\nMaterial & Methods\n40 adult male rats, their weight ranged between 300 -350 g. The rats were classified into three groups; control ( 10 rats ) were received corn oil at a dose of 10mg/kg/day by gavage once a day for 2 months.\nDiazinon ( 15 rats) were received diazinon at a dose of 10mg/kg/day dissolved in corn oil by gavage once a day for 2 months. Treated group (15rats), were received mesna 180mg/kg once a week by gavage 15 min. before administration of diazinon for 2 months. At the end of the experiment , animals were anesthetized , blood samples were taken by cardiac puncture for glucose and insulin assays & pancreas was removed and divided into 3 portions ;1st portion for histopathological study; 2nd portion for ultrastructural study ; 3rd portion for biochemical study using Elisa Kits including determination of malondialdehyde (MDA) ,tumor necrosis factor α( TNF-α), myeloperoxidase activity ( MPO), interleukin 1β( IL-1β) .\nResults\n A significant increase in the levels of MDA, TNF-α, MPO activity , IL-1β , serum glucose levels in the toxicated group with diazinon were observed , while a significant reduction was noticed in GSH & in serum insulin levels. After treatment with mesna a significant reduction was observed in the previously mentioned parameters except that there was a significant rise in GSH & in insulin levels. Histopathological & ultrastructural studies showed destruction in pancreatic tissues and the β cells were the most affected cells among the injured islets as compared with the control group .\nConclusion \nThe current study try to spot light about the effects of chronic exposure to pesticides on vital organs as pancreas also the role of oxidative stress that may be induced by them in evoking their toxicity. This study shows the role of antioxidant drugs in ameliorating or preventing the toxicity. This appears to be a promising approach that may be considered as a complementary treatment of pesticide toxicity.

According to Margaret Cool Root, a leading scholar on the ancient Near East, the royal art of the kings reflects the ideals and attitudes of the king and his courtiers, presenting, above all, an ideal view of the nature of Persian kingship. Root argues that the variegated origins and appropriated concepts of Achaemenid iconography, from the Egyptian illustrations of conquered peoples in the form of the Nine Bows to the Assyrian royal hero, create conceptual patterns that are continually replicated at Persepolis to create an official artistic program. Root asserts that the themes found in royal iconography were disseminated from the empire’s center and were not the result of individual artists’ own creativity. However, is this only representative of the rich iconography of Persepolis, or were the art and architecture of provincial palaces, including the paradeisoi (large gardens or parks) and glyptic art (artwork engraved on seals and other small finds) representative of the wider process of ‘Persianisation’? It is worth highlighting at the outset that the various approaches to governing the empire must have impacted on the archaeological record, both on the material evidence left behind and the ways in which Achaemenid influence is not detectable. Regarding the latter, Root has highlighted five factors that have combined to minimise the retrieval of Achaemenid art and architecture: the low priority given to Persian levels at archaeological sites in comparison to Achaemenid studies have progressed markedly in the intervening years, though these issues are not yet fully resolved and are particularly applicable for some of the sites under discussion here. It must also be noted here that this paper cannot aim to answer all questions raised due to the scope of the topic, but hopefully contains the scope for further research and study with the publication of new excavation reports.

Urban planning efforts to conserve urban biodiversity have often concentrated on establishing protected natural areas and corridors. While green infrastructure is important, it is critical that surrounding neighborhoods and commercial areas have minimal impacts on conserved areas. Everything from invasive exotics to storm water runoff can degrade the biological integrity of green infrastructure. In this essay, we discuss future research and strategic directions to achieve a systems approach that includes the design and management of nearby built areas to be compatible with green infrastructure. Planners develop- ers, researchers, and residents all play a role in shifting conventional development inertia to something more compatible with green infrastructure. We outline a range of processes, research, policy tools and educational strategies that could be used to engage key stakeholder groups more closely with urban biodiversity conservation.

N-acetyl-2-aryl-1,2-dihydro-(4H)-3,1-benzoxazin-4-ones efficient synthesis from the\ncondensation reaction between aromatic aldehydes and anthranilic acid in the presence of\nexcess amount of acetic anhydride catalyzed by ionic liquid [pmim]HSO4SiO2 in CH3CN\nhas been explored